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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
16.36
Human Site:
T116
Identified Species:
30
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
T116
V
K
W
Q
D
F
F
T
G
H
V
V
G
E
P
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
T116
V
K
W
Q
D
F
F
T
G
H
V
V
G
E
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
T112
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
S116
V
K
W
Q
D
F
F
S
G
H
V
V
G
E
P
Rat
Rattus norvegicus
Q9Z1K9
827
92999
S116
V
K
W
Q
D
F
F
S
G
H
V
V
G
E
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
Chicken
Gallus gallus
NP_001008682
829
93588
F116
R
V
Q
W
Q
D
F
F
T
G
H
V
V
G
E
Frog
Xenopus laevis
Q8JIY1
749
84049
Q105
T
S
H
I
Y
T
G
Q
L
F
G
E
Q
G
T
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
F113
E
V
Q
R
E
N
F
F
T
G
H
V
I
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
Y93
L
H
S
K
F
R
A
Y
A
V
D
A
D
G
N
Honey Bee
Apis mellifera
XP_623993
716
82155
V77
S
K
F
K
A
Y
E
V
N
G
D
G
E
E
K
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
F47
Q
S
V
V
H
F
E
F
L
D
Q
E
Y
V
V
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
P108
M
G
Y
L
E
D
D
P
D
S
V
V
K
M
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
100
N.A.
13.3
N.A.
93.3
93.3
N.A.
0
13.3
0
13.3
N.A.
0
13.3
6.6
13.3
P-Site Similarity:
100
100
N.A.
46.6
N.A.
100
100
N.A.
0
13.3
0
26.6
N.A.
13.3
33.3
6.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
0
8
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
31
16
8
0
8
8
16
0
8
0
0
% D
% Glu:
8
0
0
8
24
0
16
0
0
0
0
16
8
47
16
% E
% Phe:
0
0
8
0
8
39
47
24
0
8
0
0
0
0
0
% F
% Gly:
8
8
8
0
0
0
8
0
31
24
8
8
31
31
0
% G
% His:
0
8
8
0
8
0
0
0
0
31
16
0
0
0
8
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
0
16
0
0
% I
% Lys:
0
39
0
16
0
0
0
0
0
0
0
0
8
0
8
% K
% Leu:
8
0
0
8
0
0
0
0
16
0
0
8
0
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
8
0
0
8
8
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
31
% P
% Gln:
8
0
16
31
8
0
0
8
0
0
8
0
8
0
0
% Q
% Arg:
8
8
0
8
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
16
8
0
0
8
0
16
0
8
0
0
0
0
0
% S
% Thr:
8
0
0
0
0
8
8
24
24
0
0
0
0
0
8
% T
% Val:
31
16
8
8
0
0
0
8
0
8
39
54
8
8
8
% V
% Trp:
0
0
31
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
8
0
8
0
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _